The Evaluation of the Efficacy of Ketoprofen Analgesic Patches in Pain Control After Transalveolar Extraction of Impacted Third Molar
Md Shaklin Mustak Hussain1*, Ajay Kumar Pillai2, Priyanka Sharma3, Shivangini Nayak4, Anamika Juhi5
1Postgraduate Resident, Department of Oral & Maxillofacial Surgery, People's Dental Academy, Bhopal, India.
2Professor, & Head, Department of Oral & Maxillofacial Surgery, People's Dental Academy, Bhopal, India.
3Reader, Department of Oral & Maxillofacial Surgery, People's Dental Academy, Bhopal, India.
4Senior Lecturer, Department of Oral & Maxillofacial Surgery, People's Dental Academy, Bhopal, India.
5Postgraduate Resident, Department of Oral & Maxillofacial Surgery, People's Dental Academy, Bhopal, India.
*Corresponding Author: Dr. Md Shaklin Mustak Hussain, Postgraduate Resident, Department of Oral & Maxillofacial Surgery, People's Dental Academy, Bhopal, India.
https://doi.org/10.58624/SVOADE.2026.07.008
Received: February 05, 2026
Published: February 24, 2026
Citation: Hussain MSM, Pillai AK, Sharma P, Nayak S, Juhi A. The Evaluation of the Efficacy of Ketoprofen Analgesic Patches in Pain Control After Transalveolar Extraction of Impacted Third Molar. SVOA Dentistry 2026, 7:1, 57-62. doi: 10.58624/SVOADE.2026.07.008
Abstract
Background: Postoperative pain following transalveolar extraction of impacted third molar remains a significant concern for both clinicians and patients. Non-steroidal anti-inflammatory drugs (NSAIDs) are routinely prescribed; however, their oral administration is associated with gastrointestinal irritation, frequent dosing, and reduced patient compliance. Transdermal drug delivery systems provide sustained analgesia with reduced systemic exposure. Ketoprofen, a propionic acid derivative NSAID, demonstrates favorable pharmacokinetic properties for transdermal administration.
Aim: To evaluate the efficacy and safety of ketoprofen transdermal analgesic patches in controlling postoperative pain following transalveolar extraction of impacted third molar.
Materials and Methods: A clinical study was conducted on 30 ASA I patients requiring transalveolar extraction of impacted third molar. Each patient received a ketoprofen transdermal patch on the ipsilateral deltoid region after extractions. Postoperative pain was assessed using the Visual Analogue Scale (VAS) at 2, 6, 12, and 24 hours. The requirement for rescue analgesics and the occurrence of adverse effects were recorded. Statistical analysis was performed using an ANOVA test with significance set at p < 0.05.
Results: Ketoprofen transdermal patches demonstrated significantly lower mean VAS scores at 2, 6, 12, and 24 hours (p < 0.05). The need for rescue analgesics within the first 24 hours was less. No serious local or systemic adverse effects were reported.
Conclusion: Ketoprofen transdermal patches provide effective and safe postoperative analgesia following minor oral surgical procedures and may serve as a reliable alternative to conventional oral NSAIDs.
Keywords: Ketoprofen Patch, Transdermal Drug Delivery, Postoperative Pain, Minor Oral Surgery, NSAIDs
