Use of Cannabinoids in the Treatment of Orofacial Pain and Temporomandibular Disorders: A Narrative Review
Igor Leitão Marques1*, Fernanda Quaresma1
1Department of Oral and Maxillofacial Surgery – HCor Hospital, Sao Paulo, Brazil.
*Corresponding Author: Igor Leita o Marques, Department of Oral and Maxillofacial Surgery – HCor Hospital, Sao Paulo, Brazil.
https://doi.org/10.58624/SVOADE.2025.06.033
Received: October 27, 2025
Published: November 07, 2025
Citation: Marques IL, Quaresma F. Use of Cannabinoids in the Treatment of Orofacial Pain and Temporomandibular Disorders: A Narrative Review. SVOA Dentistry 2025, 6:6, 206-208. doi: 10.58624/SVOADE.2025.06.033
Abstract
The use of cannabinoids represents a promising therapeutic approach for the management of orofacial pain and temporomandibular disorders (TMD). This narrative review aimed to explore the potential mechanisms of action, clinical applications, and current scientific evidence regarding the use of cannabinoids in dentistry. A search of the recent literature was conducted, highlighting studies that demonstrate the anti-inflammatory, analgesic, and neuromodulatory properties of cannabinoids, especially cannabidiol (CBD), in the control of chronic and neuropathic pain conditions. Although clinical data remain limited, emerging evidence suggests that cannabinoids may serve as an adjunctive therapy in the treatment of TMD and orofacial pain, contributing to improved patient outcomes and quality of life. Further clinical trials are necessary to establish standardized protocols and determine the long-term safety and efficacy of these substances in dental practice.
Keywords: Cannabinoids; Cannabidiol; Orofacial Pain; Temporomandibular Disorders; Dentistry; CBD Therapy.
