Apocrine Carcinoma of the Breast in a Young Woman Managed With Oncoplastic Breast‑Conserving Surgery: A Case Report From Western Nepal
Rupesh Roshan MS1, Bandana Shah MD2*, Mukesh Yadav MD3*
1Breast Oncosurgeon, Sushil Koirala Prakhar Cancer Hospital, Khajura, Nepal.
2Department of Pathology, Nepalgunj Medical College, Kohalpur, Nepal.
3Radiation Oncologist, Sushil Koirala Prakhar Cancer Hospital, Khajura, Nepal.
*Corresponding Author: Bandana Shah MD, Department of Pathology, Nepalgunj Medical College, Kohalpur, Nepal and Mukesh Yadav MD, Radiation Oncologist, Sushil Koirala Prakhar Cancer Hospital, Khajura, Nepal.
https://doi.org/10.58624/SVOAMR.2025.03.022
Received: November 14, 2025
Published: November 28, 2025
Citation: Roshan R, Shah B, Yadav M. Apocrine Carcinoma of the Breast in a Young Woman Managed With Oncoplastic Breast‑Conserving Surgery: A Case Report From Western Nepal. SVOA Medical Research 2025, 3:6, 187-191. doi: 10.58624/SVOAMR.2025.03.022
Abstract
Background: Apocrine carcinoma of the breast is an uncommon histological variant of invasive breast cancer, representing less than 1% of all breast malignancies. Its unique cellular features and immunohistochemical profile create challenges in both diagnosis and treatment planning.
Case Presentation: A 40-year-old premenopausal woman with small breast volume presented with a palpable lump in her left breast. Core needle biopsy confirmed invasive carcinoma exhibiting apocrine differentiation. She underwent oncoplastic breast-conserving surgery using a volume-displacement technique at Sushil Koirala Prakhar Cancer Hospital, followed by adjuvant chemotherapy and radiotherapy. Surgical margins were negative, and no axillary lymph node involvement was detected. At a 12-month follow-up, the patient remains disease-free with an excellent cosmetic result.
Conclusion: This case demonstrates that oncoplastic breast-conserving surgery can be effectively performed in young women with small breast volume and uncommon tumor types such as apocrine carcinoma, providing both oncological safety and favorable aesthetic outcomes.
Keywords: Apocrine Carcinoma; Breast Cancer; Oncoplastic Surgery; Breast‑Conserving Surgery; Young Female; Nepal