Phytochemical Potential and Pharmacological Activities of Hancornia speciosa Gomes (Apocynaceae): A Systematic Review
Fábio Caboclo Moreira1, José Thyálisson da Costa Silva2, Viviane Bezerra da Silva2, Adrielle Rodrigues Costa2, Dieferson Leandro de Souza2, Janês Inês de Brito2, Anna Lídia Nunes Varela2, Daniela Jomara Caruço de Oliveira3, Lucas dos Santos Sa2, Leandro Marques Correia4, Antonio César Vieira da Silva2, Rafael de Carvalho Mendes5, Hayane Mateus Silva Gomes2, Maria Elizete Machado Generino2, Yedda Maria Lobo Soares de Matos2, Cícera Natalia Figueirêdo Leite Gondim2, Lucas Yure Santos da Silva2, José Weverton Almeida Bezerra2*
1Regional of University of Blumenau, Blumenau – SC, Brazil.
2Regional University of Cariri, Crato – CE, Brazil.
3Federal University of Paraná, Curitiba – PR, Brazil.
4Federal University of Cariri, Juazeiro do Norte – CE, Brazil.
5Paraíso Medical Faculty, Araripina - PE, Brazil.
*Corresponding Author: Prof. Dr. Jose Weverton Almeida-Bezerra, Department of Biological Chemistry, Regional University of Cariri, 63105-000, Crato, CE, Brazil.
https://doi.org/10.58624/SVOAMB.2026.07.005
Received: February 10, 2026
Published: April 08, 2026
Citation: Moreira FC, Silva JTC, Silva VB, Costa AR, Souza DL, Brito JI, Varela ALN, Oliveira DJC, Sa LS, Correia LM, Silva ACV, Mendes RC, Gomes HMS, Generino MEM, Matos YMLS, Gondim CNFL, Silva LYS, Almeida-Bezerra JW. Phytochemical Potential and Pharmacological Activities of Hancornia speciosa Gomes (Apocynaceae): A Systematic Review. SVOA Microbiology 2026, 7:2, 46-54. doi: 10.58624/SVOAMB.2026.07.005
Abstract
The relevance of Hancornia speciosa Gomes, popularly known as mangabeira, a native Brazilian species with traditional medicinal use, therefore, the main objective of this work was to carry out a critical and comprehensive evaluation of the information published about the "mangabeira", focusing on its chemical constituents, pharmacological properties and biological effects. The methodology consisted of a systematic review of the scientific literature, with a search in databases such as SCOPUS, using descriptors faithful to the phytochemistry and biological activities of the species. The results revealed a remarkable phytochemical complexity, with the predominance of phenolic compounds (such as rutin and chlorogenic acid) and cyclitols (such as bornesitol) in its various parts of the plant (leaves, bark and latex), substantiating its multiple biological activities, including antidiabetic effects, acting by inhibiting α-glucosidase, cardiovascular (antihypertensive and vasorelaxant), anti-inflammatory and leishmanicidal effects. We conclude that the integration of chemical and pharmacological data confirms the significant therapeutic potential of H. speciosa, although it highlights the need for future investigations to fully explore its value as a promising resource for phytotherapy.
Keywords: Disease Treatments, Medicinal Plant, Health, Phytotherapies, Chemistry.
