SVOA Neurology

Shalin Sheth^1*, Asim Roy¹

¹The Ohio Sleep Medicine Institute, USA.

*Corresponding Author: Shalin Sheth, The Ohio Sleep Medicine Institute, USA.

DOI: https://doi.org/10.58624/SVOANE.2026.07.014

Received: April 14, 2026

Published: May 19, 2026

Citation: Sheth S, Roy A. Clinical Outcomes of eXciteOSA Therapy: A Retrospective Chart Review. SVOA Neurology 2026, 7:3, 86-92. doi.org/10.58624/ SVOANE.2026.07.014

Abstract

Obstructive sleep apnea (OSA) is a common disorder with significant health consequences. A widespread treatment for this disorder, continuous positive airway pressure (CPAP), often has low patient adherence. The eXciteOSA device, a neuromuscular electrical stimulation (NMES) therapy, offers a non-invasive alternative that aims to address the underlying cause of OSA. This retrospective chart review of 87 patients investigated the efficacy outcomes of adherent patients (defined as ≥50% usage over 6 weeks) to eXciteOSA therapy, specifically as measured by a decrease in the Apnea-Hypopnea Index (AHI 3%; events/hour). A subset of 37 patients with both baseline and follow-up AHI 3% data was analyzed for efficacy, including a more in-depth analysis of the adherent cohort (n=34) as a per-protocol analysis. Within the adherent cohort, 52.94% (n=18) of patients demonstrated improvement in AHI 3%, 35.29% (n=12) worsened, and 11.76% (n=4) showed no change in this metric. A paired-samples t-test revealed the mean reduction in AHI 3% from baseline to follow-up did not reach statistical significance (p = 0.56). Despite this, these findings provide valuable real-world data and demonstrate a positive trend that suggests patient adherence is a critical factor for successful outcomes. Furthermore, this study highlights the need for larger, controlled studies to confirm the association between NMES therapy and efficacy.

Keywords: Obstructive Sleep Apnea (OSA), eXciteOSA Therapy, Neuromuscular Electrical Stimulation (NMES), Apnea-Hypopnea Index (AHI), Treatment Adherence