Clinical and Electrophysiological Profile of Patients with Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) in a Tertiary Care Centre
Dutta Pravallika1, Rindha V Rao1, Divya Teja Garapati1, Sireesha Yareeda1, Megha S Uppin1, Surya Prabha Turaga1, Reshma Sultana Shaik1*
1Nizam’s Institute of Medical Sciences, Hyderabad, Telangana, India, 500082
*Corresponding Author: Dr. Reshma Sultana Shaik, Assistant Professor of Neurology, Nizam’s Institute of Medical Sciences, Hyderabad, Telangana, India, 500082
https://doi.org/10.58624/SVOANE.2025.06.026
Received: October 07, 2025
Published: November 11, 2025
Citation: Pravallika D, Rao RV, Garapati DT, Yareeda S, Uppin MS, Turaga SP, Shaik RS. Clinical and Electrophysiological Profile of Patients with Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) in a Tertiary Care Centre. SVOA Neurology 2025, 6:5, 146-155. doi. 10.58624/SVOANE.2025.06.026
Abstract
Introduction: Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) is an acquired immune-mediated peripheral neuropathy. This study was undertaken to describe the clinical and electrophysiological profile of patients with CIDP from a single centre.
Aims and Objectives: 1. To study the clinical and electrophysiological profile of patients with CIDP. 2. To study the effects of treatment and their outcomes in patients with CIDP through the inflammatory neuropathy cause and treatment (INCAT) scoring system and INCAT overall disability sum score (ODSS).
Materials and Methods: It is an ambispective study conducted between July 2017 and December 2019 in the Department of Neurology, Nizam’s Institute of Medical Sciences. A structured proforma and nerve conduction studies were done.
Results: The mean age was 41.32 years. Male: Female = 38:12. Twenty-four patients had a relapsing remitting course, 24 patients had a progressive course, and 2 had an acute onset of Guillain-Barre syndrome presentation. Typical CIDP was seen in 42 (84%) patients, 5(10%) patients had Multifocal acquired demyelinating sensory and motor neuropathy (MADSAM) variant, 2 patients had pure motor variant, 1 patient had pure sensory variant, and none of them showed distal acquired demyelinating symmetric (DADS) phenotype. Slow conduction velocity was the most common observation seen in 94% patients.
Conclusions: Typical CIDP was the most common phenotype, and none of the subjects had the DADS variant; thus, we can hypothesise that the prevalence of DADS in South India is less compared to the Western studies.
Key message: CIDP is an immune-mediated disorder with various phenotypes. Treatment should be tailored made depending upon the phenotype. This is one of the largest cohorts from a single centre in South India.
Keywords: Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP), European Federation of Neurological Societies/ Peripheral Nerve Society (EFNS/PNS) criteria, Multifocal Acquired Demyelinating Sensory and motor neuropathy (MADSAM)
