Increased Levels of Idiopathic Prolactin Associated with Prominent Headaches & Stress: A Common Identity in Clinical Practice
Manik Mathur*
Consultant Neurologist & Geriatric Care, Department of Clinical Neurology (Acute Stroke Unit), C-Care Hospitals, Kampala, Uganda.
*Corresponding Author: Dr. Manik Mathur, MBBS, Post Graduate Diploma (UK), Clinical Ph.D. Neurology (UK), Consultant Neurologist & Geriatric Care, Department of Clinical Neurology (Acute Stroke Unit), C-Care Hospitals, Kampala, Uganda.
https://doi.org/10.58624/SVOANE.2025.06.030
Received: September 29, 2025
Published: November 26, 2025
Citation: Mathur M. Increased Levels of Idiopathic Prolactin Associated with Prominent Headaches & Stress: A Common Identity in Clinical Practice. SVOA Neurology 2025, 6:6, 179-181. doi. 10.58624/SVOANE.2025.06.030
Abstract
Hyperprolactinemia is characterised by an increase in prolactin blood levels (more than 100-200 ng/ml). Commonly occurring endocrine disorder in the daily clinical practice. This letter depicts the characteristic headache associated with hyperprolactinemia and the various diagnostic and treatment possibilities behind the diagnosis are explored. This paper discusses above-mentioned pathology with reference to one clinical case, A 30-year-old female suffering from chronic tension-type headache interspersed with occasional episodes of migraine without aura (as defined by the International Headache Society criteria). She had also suffered menstrual cycle alterations since the age of 14. Computed tomography (CT) and magnetic resonance imaging (MRI) scans revealed a 5 mm growth signifying micro prolactinoma. Initial management with pain killers was unsuccessful at various clinics and hospitals. Her irregular menstrual cycles pointed toward the hidden pathology. Treatment with cabergoline resulted in near-complete resolution of headaches and the changes towards regularity of menstrual cycle, with prolactin levels returned to normal. Additionally, High prolactin levels have a significant effect on the integrity and permeability of the Blood-Brain Barrier. Furthermore, the delusional impact of Covid-19 on high levels of prolactin is a matter of concern.
Keywords: Idiopathic Prolactin, Headaches & Stress, Computed tomography (CT)
